Although the monolithic stationary phases suitable for separations were introduced in the 1990s [1,2,3], the idea of using a “continuous block of the porous gel structure” as stationary phase was discussed in Analyst by R. L. M. Synge, A. J. P. Martin, and A. Tiselius as longs ago as in 1952. Both equilibrium and kinetic [...]
Because of lack of small pores it is difficult to separate small molecules with polymer monoliths in isocratic mode. We have prepared monolithic capillary columns and then hypercrosslinked them to afford a monolith containing an array of small pores [1].
Many applications of porous materials in areas such as catalysis, adsorption, ion exchange, chromatography, and solid phase synthesis rely on the intimate contact with a surface that supports the active sites.
The generally accepted mechanism of pore formation in organic polymer monolihts during a typical polymerization in the presence of a precipitant is following [1,2]:
As a new type of chromatographic stationary phase, monoliths have been subjected to intensive study in the last years. They differ from other supports mainly in their characteristic structure, which results in the improved chromatographic properties.
University of Pardubice at HPLC 2012
PF 2012
Remotely detected NMR and hypercrosslinked monoliths
HPLC 2011 – preselection
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